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SPELL is an acronym for Split Protein Reassembly by Ligands or Light. SPELL server predicts potential split sites in proteins such that two halves of a splitted protein being attached to a couple of other proteins (that dimerize upon ligand or light stimulation) can reassemble into a full protein upon ligand or light stimulation. The server ranges potential split sites according to the degree of prediction reliability.

More details are available in the following publication:

Dagliyan, Onur, Andrey Krokhotin, Irem Ozkan-Dagliyan, Alexander Deiters, Channing J. Der, Klaus M. Hahn, and Nikolay V. Dokholyan. "Computational design of chemogenetic and optogenetic split proteins." Nature Communications 9, no. 1 (2018): 4042.


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For technical support, please contact ResearchComputing@pennstatehealth.psu.edu.

For all other questions and comments, please contact dokh@psu.edu, krokh@stanford.edu, and jwang10@pennstatehealth.psu.edu.